PROTOCOL OF A PHASE II STUDY TO EVALUATE THE EFFICACY AND SAFETY OF DEEP-INSPIRATION BREATH-HOLD DAILY ONLINE ADAPTIVE RADIOTHERAPY FOR CENTRALLY LOCATED LUNG TUMOURS (PUDDING STUDY)

Protocol of a phase II study to evaluate the efficacy and safety of deep-inspiration breath-hold daily online adaptive radiotherapy for centrally located lung tumours (PUDDING study)

Abstract Background Centrally located lung tumours present a challenge because of their tendency to exhibit symptoms such as airway obstruction, atelectasis, and bleeding.Surgical resection of these tumours often requires sacrificing the lungs, making definitive radiotherapy the preferred alternative to avoid pneumonectomy.However, the proximity of

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